Carbamazepine
Anticonvulsant • Last reviewed 2025-09-24
Brands: Tegretol
Sources updated 2025 • 1 references
General Information
Anticonvulsant
Dosage & Administration
Typical dose range: 400–1200 mg/day (in divided doses)
Therapeutic level: 4000–12000 ng/mL
Indications (label)
—
View labelExact
Mechanism (brief)
Voltage‑gated sodium channel blocker; reduces high‑frequency neuronal firing.
Metabolism & Half‑life
- Metabolism: Strong CYP3A4 inducer; autoinduction; epoxide metabolite.
- Half‑life: ~12–17 h (after autoinduction).
Therapeutic Drug Monitoring (TDM)
Recommended: Yes
Reference range: 4000–12000 ng/mL
Sampling: Trough
Source: AGNP 2018
References
- Carbamazepine labelExact (2025)
- Carbamazepine‑induced hyponatremia: risk and management — Review (2019)
- Review of carbamazepine-induced hyponatremia. — Progress in Neuro-Psychopharmacology & Biological Psychiatry (1994)