clonidine
Adjunctive therapy • Brands: CATAPRES
Last reviewed: 2025-12-30
General information
- Primary label indications include: Hypertension (label).
- Class: Adjunctive therapy
- Common US brands: CATAPRES
- Therapeutic drug monitoring not routinely recommended.
- Last reviewed: 2025-12-30
Dosing & forms
- Forms/strengths: —
- Frequency: —
- Food: —
- Typical range: —
Mechanism (brief)
Alpha-2 adrenergic agonist; reduces central sympathetic outflow (antihypertensive; also used off-label in psychiatry).
Metabolism & Half‑life
- Metabolism: Hepatic metabolism (multiple pathways)
- Half‑life: Single-dose range 12–16 h
Therapeutic Drug Monitoring (TDM)
Recommended: No
Monitoring highlights
- —
Sources
- Clonidine hydrochloride tablets prescribing information — DailyMed (2025)
- Attention deficit hyperactivity disorder (NICE guideline NG87) — NICE (2018)
- Clinical Practice Guideline for the Diagnosis, Evaluation, and Treatment of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents — Pediatrics (2019)
- Comparative efficacy and tolerability of medications for ADHD (systematic review and network meta-analysis) — Lancet Psychiatry (2018)