Educational only — not medical advice. If you’re in crisis or thinking about suicide: call or text 988 (U.S.) or your local emergency number. Support resources. Under construction and review—see the updates log.
Adjunctive therapy • Brands: Auvelity
Last reviewed: 2026-02-23
Combination antidepressant pairing dextromethorphan (NMDA receptor antagonist and sigma-1 receptor agonist) with bupropion, which inhibits CYP2D6 to increase dextromethorphan exposure; used for major depressive disorder.
Recommended: No