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Lamotrigine

Mood stabilizer • Last reviewed 2025-09-23

Brands: Lamictal

Sources updated 2025 • 1 references

Summary

General Information

Indicated for: Maintenance treatment of bipolar I disorder; seizures (various types). Mood stabilizer

Dosage & Administration

Typical dose range: 100–400 mg/day (maintenance)

Indications (label)

Maintenance treatment of bipolar I disorder; seizures (various types).

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Mechanism (brief)

Blocks voltage-gated sodium channels; decreases glutamate release.

Metabolism & Half‑life

  • Metabolism: Hepatic glucuronidation (UGT1A4).
  • Half‑life: ~25–33 h (monotherapy).

Therapeutic Drug Monitoring (TDM)

Recommended: No

References