Skip to content

Lithium

Mood stabilizer • Last reviewed 2025-09-23

Brands: Lithobid

Sources updated 2025 • 1 references

Summary

General Information

Indicated for: Acute manic and maintenance treatment of bipolar I disorder. Mood stabilizer

Dosage & Administration

Typical dose range: 600–1800 mg/day (in divided doses)

Therapeutic level: 0.6–1.2 mEq/L (12 h trough; acute 0.8–1.2).

Indications (label)

Acute manic and maintenance treatment of bipolar I disorder.

View labelExact

Mechanism (brief)

Modulates second messenger systems; neuroprotective/neurotrophic effects (exact MoA unknown).

Metabolism & Half‑life

  • Metabolism: Not metabolized; renal excretion.
  • Half‑life: ~18–36 h (longer in elderly).

Therapeutic Drug Monitoring (TDM)

Recommended: Yes

Sampling: 12‑h trough

Source: AGNP 2018

References