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Loxapine

FGA • Last reviewed 2025-09-26

Brands: Loxitane, Adasuve

Sources updated 2025 • 1 references

Summary

General Information

Indicated for: Schizophrenia; acute agitation associated with schizophrenia or bipolar I (inhaled). First‑generation antipsychotic (FGA)

Dosage & Administration

Typical dose range: 20–100 mg/day (divided)

Indications (label)

Schizophrenia; acute agitation associated with schizophrenia or bipolar I (inhaled).

View labelExact

Mechanism (brief)

Mid-potency D2 and 5‑HT2A antagonist with H1/M1 blockade.

Metabolism & Half‑life

  • Metabolism: CYP1A2, CYP3A4, CYP2D6 to active metabolites.
  • Half‑life: ~6–8 h (parent).

Therapeutic Drug Monitoring (TDM)

Recommended: No

References