Educational only — not medical advice. If you’re in crisis or thinking about suicide: call or text 988 (U.S.) or your local emergency number. Support resources. Under construction and review—see the updates log.
Adjunctive therapy • Brands: Wakix
Last reviewed: 2025-12-30
Histamine H3 receptor inverse agonist/antagonist (pitolisant) indicated for excessive daytime sleepiness and cataplexy in narcolepsy; non-scheduled but has clinically important QT prolongation risk at higher exposures and dose adjustments for CYP2D6 status and interacting medications.
Recommended: No