Quetiapine

SGA • Last reviewed 2025-09-23

Brands: Seroquel

Sources updated 2025 • 1 references

General Information

Indicated for: Schizophrenia; acute manic/mixed episodes; bipolar depression; adjunct for major depressive disorder. Second‑generation antipsychotic (SGA)

Dosage & Administration

Typical dose range: 300–800 mg/day

Indications (label)

Schizophrenia; acute manic/mixed episodes; bipolar depression; adjunct for major depressive disorder.

View labelExact

Mechanism (brief)

Antagonist at 5-HT2A and D2 (transient), strong H1 and alpha-1 activity.

Metabolism & Half‑life

Metabolism: CYP3A4 primary.
Half‑life: ~6 h (IR).

Therapeutic Drug Monitoring (TDM)

Recommended: No

References

Quetiapine labelExact (2025)
Pharmacological treatment for bipolar mania: network meta-analysis of RCTs. — Molecular Psychiatry (2022)
Efficacy of Quetiapine in Bipolar Depression: Meta‑analysis — Meta‑analysis (2020)
Quetiapine in schizophrenia and bipolar disorder: systematic review — Systematic review (2019)