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Amitriptyline

TCA • Last reviewed 2025-09-27

Brands: Elavil

Sources updated 2025 • 1 references

Summary

General Information

Indicated for: Depression; also used off-label for neuropathic pain and migraine prophylaxis. TCA

Dosage & Administration

Typical dose range: 75–150 mg/day (divided or nightly)

Therapeutic level: Combined amitriptyline + nortriptyline 80–200 ng/mL.

Indications (label)

Depression; also used off-label for neuropathic pain and migraine prophylaxis.

View labelExact

Mechanism (brief)

Tricyclic antidepressant; serotonin and norepinephrine reuptake inhibition with strong anticholinergic effect.

Metabolism & Half‑life

  • Metabolism: CYP2D6 and CYP2C19 to nortriptyline.
  • Half‑life: ~21–24 h.

Therapeutic Drug Monitoring (TDM)

Recommended: No

References