SMI medication toolkit

Quick shortcuts

• Compare medications (dosing highlights, monitoring reminders, and risk badges).
• LAI navigator (intervals, oral overlap, and injection considerations).
• Evidence library (filter guidelines, RCTs, and reviews).
• Updates log (what changed and when).

Antipsychotic start: baseline checklist

Use this to organize questions for a clinician visit and confirm what monitoring is appropriate for the specific drug and patient.

• Indication and target symptoms (positive, negative, mood, agitation).
• Baseline vitals and weight/BMI; plan for metabolic follow-up.
• Medication interaction review (QT-prolongers, CNS depressants, CYP inhibitors/inducers).
• EPS/akathisia plan (what to watch for and when to call).
• If QT risk factors exist, discuss whether an ECG is appropriate (drug-specific; see compare QTc badge).

Metabolic monitoring (SGAs)

Many SGAs can affect weight, glucose, and lipids. Monitoring cadence varies by guideline and patient factors — use the drug’s Monitoring section and local protocols.

• Track weight/BMI at baseline and periodically.
• Check fasting glucose/HbA1c and lipids per protocol (baseline and follow-up).
• If weight gain becomes a barrier, discuss options (switching, lifestyle support, or metabolic adjuncts such as metformin).

EPS & TD: common supports

These pages cover commonly discussed symptom-targeted adjuncts. Always confirm diagnosis and management with a clinician.

• Acute dystonia/parkinsonism: anticholinergics such as benztropine or trihexyphenidyl.
• Akathisia: commonly discussed options include propranolol (drug- and patient-specific).
• Tardive dyskinesia: VMAT2 inhibitors such as valbenazine or deutetrabenazine.
• If symptoms emerge, use Compare to review EPS risk badges across options: common SGAs comparison.

LAI planning

• Start with the LAI navigator to review interval and oral overlap basics.
• Use Compare to align parent medication considerations: LAI parents preset.
• Confirm administration site, observation requirements, and missed-dose policy from the official label.

Clozapine basics

• Review the clozapine profile for monitoring tables and boxed warning context.
• Plan labs, infection symptom counseling, and follow-up structure before titration changes.
• Browse guidelines and reviews in Evidence: clozapine guidelines.