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Doxepin

TCA • Last reviewed 2025-09-27

Brands: Sinequan

Sources updated 2025 • 1 references

Summary

General Information

Indicated for: Depression and anxiety disorders; insomnia (low-dose). TCA

Dosage & Administration

Typical dose range: 75–300 mg/day (divided or nightly)

Therapeutic level: Combined doxepin + nordoxepin 150–250 ng/mL.

Indications (label)

Depression and anxiety disorders; insomnia (low-dose).

View labelExact

Mechanism (brief)

Tricyclic antidepressant; potent H1 blockade with serotonin/norepinephrine reuptake inhibition.

Metabolism & Half‑life

  • Metabolism: CYP2D6/CYP2C19 to nordoxepin.
  • Half‑life: ~28–31 h.

Therapeutic Drug Monitoring (TDM)

Recommended: No

References