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Duloxetine

SNRI • Last reviewed 2025-09-26

Brands: Cymbalta

Sources updated 2025 • 1 references

Summary

General Information

Indicated for: Major depressive disorder; generalized anxiety disorder; diabetic peripheral neuropathic pain; fibromyalgia; chronic musculoskeletal pain. SNRI

Dosage & Administration

Typical dose range: 40–120 mg/day (once or divided BID)

Indications (label)

Major depressive disorder; generalized anxiety disorder; diabetic peripheral neuropathic pain; fibromyalgia; chronic musculoskeletal pain.

View labelExact

Mechanism (brief)

Serotonin and norepinephrine reuptake inhibition; weak dopamine reuptake at high doses.

Metabolism & Half‑life

  • Metabolism: Extensive hepatic metabolism via CYP1A2 and CYP2D6.
  • Half‑life: ~12 h; steady state in ~3 days.

Therapeutic Drug Monitoring (TDM)

Recommended: No

References