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Fluoxetine

SSRI • Last reviewed 2025-09-23

Brands: Prozac

Sources updated 2025 • 1 references

Summary

General Information

Indicated for: Fluoxetine is a selective serotonin reuptake inhibitor indicated for: ( 1 ) Acute and maintenance treatment of Major Depressive Disorder (MDD) (1) Acute and maintenance treatment of Obsessive Compulsive Disorder (OCD) (1) Acute and maintenance treatment of Bulimia Nervosa (1) Acute treatment of Panic Disorder, with or without agoraphobia (1) SSRI

Dosage & Administration

Typical dose range: 20–60 mg/day

Indications (label)

Fluoxetine is a selective serotonin reuptake inhibitor indicated for: ( 1 ) Acute and maintenance treatment of Major Depressive Disorder (MDD) (1) Acute and maintenance treatment of Obsessive Compulsive Disorder (OCD) (1) Acute and maintenance treatment of Bulimia Nervosa (1) Acute treatment of Panic Disorder, with or without agoraphobia (1)

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Mechanism (brief)

Selective serotonin reuptake inhibitor (SSRI).

Metabolism & Half‑life

  • Metabolism: CYP2D6 inhibitor; long half‑life metabolite (norfluoxetine).
  • Half‑life: Long (days) including metabolite.

Therapeutic Drug Monitoring (TDM)

Recommended: No

References