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Imipramine

TCA • Last reviewed 2025-09-27

Brands: Tofranil

Sources updated 2025 • 1 references

Summary

General Information

Indicated for: Depression; childhood nocturnal enuresis. TCA

Dosage & Administration

Typical dose range: 100–200 mg/day (divided)

Therapeutic level: Combined imipramine + desipramine 150–300 ng/mL.

Indications (label)

Depression; childhood nocturnal enuresis.

View labelExact

Mechanism (brief)

Tricyclic antidepressant; serotonin and norepinephrine reuptake inhibition with anticholinergic activity.

Metabolism & Half‑life

  • Metabolism: CYP2D6/CYP1A2 to desipramine.
  • Half‑life: ~19–24 h.

Therapeutic Drug Monitoring (TDM)

Recommended: No

References