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Maprotiline

Tetracyclic • Last reviewed 2025-09-27

Brands: Ludiomil

Sources updated 2025 • 1 references

Summary

General Information

Indicated for: Depressive disorders with neurovegetative features. Tetracyclic

Dosage & Administration

Typical dose range: 100–225 mg/day (divided or nightly)

Therapeutic level: Target plasma 200–400 ng/mL (therapeutic drug monitoring).

Indications (label)

Depressive disorders with neurovegetative features.

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Mechanism (brief)

Tetracyclic antidepressant; potent norepinephrine reuptake inhibition with antihistamine effects.

Metabolism & Half‑life

  • Metabolism: CYP2D6 to active metabolites; elimination largely renal.
  • Half‑life: ~51–52 h.

Therapeutic Drug Monitoring (TDM)

Recommended: No

References