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Mirtazapine

NaSSA • Last reviewed 2025-09-26

Brands: Remeron

Sources updated 2025 • 1 references

Summary

General Information

Indicated for: Major depressive disorder. NaSSA

Dosage & Administration

Typical dose range: 15–45 mg at bedtime

Indications (label)

Major depressive disorder.

View labelExact

Mechanism (brief)

Central presynaptic α2 antagonist; increases noradrenergic and serotonergic transmission with 5-HT2/5-HT3 antagonism.

Metabolism & Half‑life

  • Metabolism: Hepatic metabolism via CYP1A2, CYP2D6, and CYP3A4.
  • Half‑life: ~20–40 h (longer in hepatic/renal impairment).

Therapeutic Drug Monitoring (TDM)

Recommended: No

References