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Nortriptyline

TCA • Last reviewed 2025-09-27

Brands: Pamelor

Sources updated 2025 • 1 references

Summary

General Information

Indicated for: Depression (particularly endogenous); consider cardiac precautions. TCA

Dosage & Administration

Typical dose range: 50–150 mg/day (divided or once nightly)

Therapeutic level: Target 50–150 ng/mL (therapeutic drug monitoring).

Indications (label)

Depression (particularly endogenous); consider cardiac precautions.

View labelExact

Mechanism (brief)

Tricyclic antidepressant; primarily norepinephrine reuptake inhibition with anticholinergic properties.

Metabolism & Half‑life

  • Metabolism: CYP2D6 to 10-hydroxynortriptyline; genotype affects clearance.
  • Half‑life: ~18–90 h.

Therapeutic Drug Monitoring (TDM)

Recommended: No

References