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Paroxetine

SSRI • Last reviewed 2025-09-26

Brands: Paxil, Paxil CR

Sources updated 2025 • 1 references

Summary

General Information

Indicated for: Major depressive disorder; obsessive-compulsive disorder; panic disorder; social anxiety disorder; generalized anxiety disorder; posttraumatic stress disorder; premenstrual dysphoric disorder. SSRI

Dosage & Administration

Typical dose range: 20–50 mg/day (IR); 25–62.5 mg/day (CR)

Indications (label)

Major depressive disorder; obsessive-compulsive disorder; panic disorder; social anxiety disorder; generalized anxiety disorder; posttraumatic stress disorder; premenstrual dysphoric disorder.

View labelExact

Mechanism (brief)

Selective serotonin reuptake inhibitor (SSRI).

Metabolism & Half‑life

  • Metabolism: Extensive CYP2D6 metabolism; potent CYP2D6 inhibitor.
  • Half‑life: ~21 h (nonlinear kinetics).

Therapeutic Drug Monitoring (TDM)

Recommended: No

References