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Perphenazine

FGA • Last reviewed 2025-09-26

Brands: Trilafon

Sources updated 2025 • 1 references

Summary

General Information

Indicated for: Schizophrenia; severe nausea and vomiting (short-term). First‑generation antipsychotic (FGA)

Dosage & Administration

Typical dose range: 16–64 mg/day (divided)

Indications (label)

Schizophrenia; severe nausea and vomiting (short-term).

View labelExact

Mechanism (brief)

Mid-potency phenothiazine D2 antagonist with moderate anticholinergic activity.

Metabolism & Half‑life

  • Metabolism: CYP2D6, CYP1A2, CYP3A4.
  • Half‑life: ~10 h.

Therapeutic Drug Monitoring (TDM)

Recommended: No

References