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Phenelzine

MAOI • Last reviewed 2025-09-27

Brands: Nardil

Sources updated 2025 • 1 references

Summary

General Information

Indicated for: Treatment-resistant depression; atypical depression. MAOI

Dosage & Administration

Typical dose range: 45–90 mg/day (divided)

Indications (label)

Treatment-resistant depression; atypical depression.

View labelExact

Mechanism (brief)

Irreversible nonselective MAO inhibitor increasing serotonin, norepinephrine, and dopamine.

Metabolism & Half‑life

  • Metabolism: Acetylation (NAT2) and CYP1A2.
  • Half‑life: ~12 h (pharmacodynamic effect 7–14 days).

Therapeutic Drug Monitoring (TDM)

Recommended: No

References