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Protriptyline

TCA • Last reviewed 2025-09-27

Brands: Vivactil

Sources updated 2025 • 1 references

Summary

General Information

Indicated for: Depression; adjunct for narcolepsy-related somnolence. TCA

Dosage & Administration

Typical dose range: 15–60 mg/day (divided daytime doses)

Therapeutic level: Therapeutic window 70–250 ng/mL.

Indications (label)

Depression; adjunct for narcolepsy-related somnolence.

View labelExact

Mechanism (brief)

Secondary amine TCA; increases norepinephrine with minimal sedation.

Metabolism & Half‑life

  • Metabolism: CYP2D6/CYP2C19 to active metabolites.
  • Half‑life: ~54 h.

Therapeutic Drug Monitoring (TDM)

Recommended: No

References