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Selegiline

MAOI • Last reviewed 2025-09-27

Brands: Eldepryl, Zelapar

Sources updated 2025 • 1 references

Summary

General Information

Indicated for: Adjunctive treatment of major depressive disorder (with dietary precautions at higher doses). MAOI

Dosage & Administration

Typical dose range: 5 mg twice daily (tablets) or 1.25–2.5 mg ODT once daily

Indications (label)

Adjunctive treatment of major depressive disorder (with dietary precautions at higher doses).

View labelExact

Mechanism (brief)

Selective MAO-B inhibition at low doses; nonselective at ≥10 mg/day.

Metabolism & Half‑life

  • Metabolism: Hepatically via CYP2B6/CYP2C19/CYP3A4 to amphetamine-like metabolites.
  • Half‑life: ~10 h (pharmacodynamic effect longer).

Therapeutic Drug Monitoring (TDM)

Recommended: No

References