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Sertraline

SSRI • Last reviewed 2025-09-23

Brands: Zoloft

Sources updated 2025 • 1 references

Summary

General Information

Indicated for: Sertraline hydrochloride tablets are a selective serotonin reuptake inhibitor (SSRI) indicated for the treatment of ( 1 ): • Major depressive disorder (MDD) • Obsessive-compulsive disorder (OCD) • Panic disorder (PD) • Posttraumatic stress disorder (PTSD) • Social anxiety disorder (SAD) • Premenstrual dysphoric disorder (PMDD) SSRI

Dosage & Administration

Typical dose range: 50–200 mg/day

Indications (label)

Sertraline hydrochloride tablets are a selective serotonin reuptake inhibitor (SSRI) indicated for the treatment of ( 1 ): • Major depressive disorder (MDD) • Obsessive-compulsive disorder (OCD) • Panic disorder (PD) • Posttraumatic stress disorder (PTSD) • Social anxiety disorder (SAD) • Premenstrual dysphoric disorder (PMDD)

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Mechanism (brief)

Selective serotonin reuptake inhibitor (SSRI).

Metabolism & Half‑life

  • Metabolism: Multiple CYPs; fewer DDIs relative to fluoxetine/paroxetine.
  • Half‑life: ~26 h.

Therapeutic Drug Monitoring (TDM)

Recommended: No

References