Skip to content

Tranylcypromine

MAOI • Last reviewed 2025-09-27

Brands: Parnate

Sources updated 2025 • 1 references

Summary

General Information

Indicated for: Major depressive disorder in patients not responsive to alternative therapies. MAOI

Dosage & Administration

Typical dose range: 20–60 mg/day (divided)

Indications (label)

Major depressive disorder in patients not responsive to alternative therapies.

View labelExact

Mechanism (brief)

Irreversible MAOI increasing serotonin, norepinephrine, and dopamine.

Metabolism & Half‑life

  • Metabolism: CYP2A6 and CYP2C19; rapid onset due to amphetamine-like structure.
  • Half‑life: ~2 h (pharmacodynamic effect 7 days).

Therapeutic Drug Monitoring (TDM)

Recommended: No

References