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Venlafaxine

SNRI • Last reviewed 2025-09-26

Brands: Effexor XR

Sources updated 2025 • 1 references

Summary

General Information

Indicated for: Major depressive disorder; generalized anxiety disorder; social anxiety disorder; panic disorder. SNRI

Dosage & Administration

Typical dose range: 75–225 mg/day (XR)

Indications (label)

Major depressive disorder; generalized anxiety disorder; social anxiety disorder; panic disorder.

View labelExact

Mechanism (brief)

Serotonin-norepinephrine reuptake inhibitor; dose-dependent norepinephrine engagement.

Metabolism & Half‑life

  • Metabolism: CYP2D6 to active O-desmethylvenlafaxine; minor CYP3A4.
  • Half‑life: ~5 h (parent); ~11 h active metabolite (XR smooths peaks).

Therapeutic Drug Monitoring (TDM)

Recommended: No

References