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Vortioxetine

Multimodal antidepressant • Last reviewed 2025-09-26

Brands: Trintellix

Sources updated 2025 • 1 references

Summary

General Information

Indicated for: Major depressive disorder. Multimodal antidepressant

Dosage & Administration

Typical dose range: 10–20 mg once daily

Indications (label)

Major depressive disorder.

View labelExact

Mechanism (brief)

Serotonin transporter inhibition plus 5-HT receptor modulation (5-HT1A agonist, 5-HT1B partial agonist, 5-HT3/5-HT7 antagonist).

Metabolism & Half‑life

  • Metabolism: CYP2D6 primary; CYP3A4 and CYP2C19 contribute.
  • Half‑life: ~66 h.

Therapeutic Drug Monitoring (TDM)

Recommended: No

References