alprazolam
Adjunctive therapy • Brands: XANAX, XANAX XR
Last reviewed: 2025-12-28
General information
- Class: Adjunctive therapy
- Common US brands: XANAX, XANAX XR
- Therapeutic drug monitoring not routinely recommended.
- Last reviewed: 2025-12-28
Dosing & forms
- Forms/strengths: —
- Frequency: —
- Food: —
- Typical range: —
Mechanism (brief)
Benzodiazepine; positive allosteric modulator of GABA-A receptors.
Metabolism & Half‑life
- Metabolism: CYP3A4
- Half‑life: Single-dose mean 11.2 h; Single-dose range 6.3–26.9 h
Therapeutic Drug Monitoring (TDM)
Recommended: No
Monitoring highlights
- —
Sources
- Xanax (alprazolam) prescribing information — DailyMed (2025)
- ASAM guideline on benzodiazepines — Journal of Addiction Medicine (2020)
- Evidence-based pharmacological treatment of anxiety disorders — Depression and Anxiety (2014)
- Guidelines for the pharmacological treatment of anxiety disorders, obsessive-compulsive disorder and posttraumatic stress disorder in primary care — International Journal of Psychiatry in Clinical Practice (2012)