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Looking for condition overviews? Visit the care hubs: schizophrenia, bipolar, depression, anxiety, insomnia, long-acting injectables, SMI toolkit, and support resources.
Oral Antipsychotics
Second Generation Antipsychotics (SGAs)
- aripiprazole (ABILIFY)
- aripiprazole (Asimtufii) (ABILIFY ASIMTUFII)
- aripiprazole lauroxil (ARISTADA, ARISTADA INITIO)
- aripiprazole monohydrate (ABILIFY MAINTENA)
- asenapine (Saphris, Secuado)
- brexpiprazole (REXULTI)
- cariprazine (VRAYLAR)
- chlorpromazine (Thorazine)
- clozapine (CLOZARIL)
- fluphenazine decanoate (PROLIXIN DECANOATE)
- haloperidol decanoate (HALDOL DECANOATE)
- iloperidone (Fanapt)
- lumateperone (CAPLYTA)
- lurasidone (LATUDA)
- olanzapine (ZYPREXA)
- olanzapine fluoxetine (Symbyax)
- olanzapine pamoate (ZYPREXA RELPREVV)
- olanzapine samidorphan (Lybalvi)
- paliperidone (INVEGA, INVEGA SUSTENNA, INVEGA TRINZA, INVEGA HAFYERA)
- paliperidone palmitate (INVEGA SUSTENNA, INVEGA TRINZA, INVEGA HAFYERA)
- pimavanserin (Nuplazid)
- pimozide (Orap)
- quetiapine (SEROQUEL)
- risperidone (RISPERDAL)
- risperidone (Perseris) (PERSERIS)
- risperidone (Uzedy) (UZEDY)
- risperidone microspheres (RISPERDAL CONSTA)
- thioridazine (Mellaril)
- thiothixene (Navane)
- trifluoperazine (Stelazine)
- ziprasidone (GEODON)
First Generation Antipsychotics (FGAs)
Long‑acting Injectable Antipsychotics (LAIs)
Mood Stabilizers
Adjunctive Medications
Adjunctive agents include a small set of commonly used SMI supports (for example EPS/TD management and metabolic support).
Antidepressants (33)
- amitriptyline (Elavil)
- amoxapine (Asendin)
- bupropion (WELLBUTRIN)
- citalopram (Celexa)
- clomipramine (Anafranil)
- desipramine (Norpramin)
- desvenlafaxine (Pristiq)
- dextromethorphan bupropion (Auvelity)
- doxepin (Sinequan, Silenor)
- duloxetine (Cymbalta)
- escitalopram (Lexapro)
- fluoxetine (PROZAC)
- fluvoxamine (Luvox)
- imipramine (Tofranil)
- isocarboxazid (Marplan)
- levomilnacipran (Fetzima)
- maprotiline (Ludiomil)
- mirtazapine (Remeron)
- nefazodone (Serzone)
- nortriptyline (Pamelor)
- paroxetine (Paxil, Paxil CR)
- phenelzine (Nardil)
- protriptyline (Vivactil)
- selegiline (Eldepryl, Zelapar)
- selegiline transdermal system (EMSAM)
- sertraline (ZOLOFT)
- tranylcypromine (Parnate)
- trazodone (DESYREL, OLEPTRO)
- trimipramine (Surmontil)
- venlafaxine (Effexor XR)
- vilazodone (Viibryd)
- vortioxetine (Trintellix)
- zuranolone (Zurzuvae)
Ketamine & rapid-acting antidepressants (2)
Benzodiazepines (12)
Sleep & circadian agents (14)
- calcium, magnesium, potassium, and sodium oxybates (Xywav)
- daridorexant (QUVIVIQ)
- diphenhydramine (BENADRYL)
- doxylamine (UNISOM)
- eszopiclone (LUNESTA)
- lemborexant (DAYVIGO)
- melatonin
- ramelteon (ROZEREM)
- sodium oxybate (Xyrem)
- sodium oxybate extended-release (Lumryz)
- suvorexant (BELSOMRA)
- tasimelteon (Hetlioz, Hetlioz LQ)
- zaleplon (SONATA)
- zolpidem (AMBIEN, AMBIEN CR)
ADHD & wakefulness agents (14)
- amphetamine / dextroamphetamine (ADDERALL, ADDERALL XR, MYDAYIS)
- armodafinil (Nuvigil)
- atomoxetine (STRATTERA)
- clonidine (CATAPRES)
- clonidine ER (KAPVAY)
- dexmethylphenidate (FOCALIN, FOCALIN XR)
- guanfacine (TENEX)
- guanfacine ER (INTUNIV)
- lisdexamfetamine (VYVANSE)
- methylphenidate (RITALIN, CONCERTA, DAYTRANA, METADATE CD, QUILLIVANT XR)
- modafinil (Provigil)
- pitolisant (Wakix)
- solriamfetol (Sunosi)
- viloxazine (Qelbree)
Substance use treatment & harm reduction (11)
Metabolic & weight management (4)
Other adjunctive medications (17)
- amantadine (Symmetrel, Gocovri, Osmolex ER)
- benztropine (Cogentin)
- buspirone (BUSPAR)
- deutetrabenazine (Austedo, Austedo XR)
- gabapentin (NEURONTIN)
- gabapentin enacarbil (Horizant)
- hydroxyzine (VISTARIL, ATARAX)
- metformin (Glucophage, Glucophage XR, Fortamet, Glumetza)
- pramipexole (Mirapex)
- prazosin (MINIPRESS)
- pregabalin (LYRICA, LYRICA CR)
- promethazine (PHENERGAN)
- propranolol (INDERAL, INDERAL LA)
- ropinirole (Requip)
- topiramate (Topamax, Trokendi XR, Qudexy XR)
- trihexyphenidyl (Artane)
- valbenazine (INGREZZA)