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Bupropion

NDRI • Last reviewed 2025-09-23

Brands: Wellbutrin

Sources updated 2025 • 1 references

Summary

General Information

Indicated for: Bupropion hydrochloride extended-release tablet (XL) is an aminoketone antidepressant, indicated for: treatment of major depressive disorder (MDD) ( 1.1 ) prevention of seasonal affective disorder (SAD) ( 1.2 ) NDRI

Dosage & Administration

Typical dose range: 150–450 mg/day (IR/SR/XL)

Indications (label)

Bupropion hydrochloride extended-release tablet (XL) is an aminoketone antidepressant, indicated for: treatment of major depressive disorder (MDD) ( 1.1 ) prevention of seasonal affective disorder (SAD) ( 1.2 )

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Mechanism (brief)

Norepinephrine–dopamine reuptake inhibitor (NDRI).

Metabolism & Half‑life

  • Metabolism: CYP2B6; active metabolites.
  • Half‑life: ~21 h (parent).

Therapeutic Drug Monitoring (TDM)

Recommended: No

References