bupropion
Adjunctive therapy • Brands: WELLBUTRIN
Last reviewed: 2026-02-12
General information
- Class: Adjunctive therapy
- Common US brands: WELLBUTRIN
- Therapeutic drug monitoring not routinely recommended.
- Last reviewed: 2026-02-12
Dosing & forms
- Forms/strengths: —
- Frequency: —
- Food: —
- Typical range: —
Mechanism (brief)
Norepinephrine–dopamine reuptake inhibitor (NDRI).
Metabolism & Half‑life
- Metabolism: CYP2B6
- Half‑life: Steady-state mean 21 h
Therapeutic Drug Monitoring (TDM)
Recommended: No
Monitoring highlights
- —
Sources
- WELLBUTRIN XL (bupropion hydrochloride) prescribing information — DailyMed (2026)
- Seasonal affective disorder and its prevention by anticipatory treatment with bupropion XL — Biological Psychiatry (2005)
- Clinical efficacy of bupropion in the management of smoking cessation — Drugs (2002)
- APA Clinical Practice Guideline for the Treatment of Depression — American Psychiatric Association (2023)
- Comparative efficacy of antidepressants for major depressive disorder: network meta-analysis — The Lancet (2018)