Bupropion

General information

Indicated for: Bupropion hydrochloride extended-release tablets (SR) are an aminoketone antidepressant, indicated for the treatment of major depressive disorder (MDD). ( 1 )

Dosing & forms

• Forms/strengths: —
• Frequency: —
• Food: —
• Typical range: 150–450 mg/day (IR/SR/XL)

Mechanism (brief)

Norepinephrine–dopamine reuptake inhibitor (NDRI).

Metabolism & Half‑life

• Metabolism: CYP2B6, active metabolites.
• Half‑life: ~21 h (parent).

Therapeutic Drug Monitoring (TDM)

Recommended: No

Monitoring highlights

• —

Sources

• Bupropion label — DailyMed (2025)