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Clomipramine

TCA • Last reviewed 2025-09-27

Brands: Anafranil

Sources updated 2025 • 1 references

Summary

General Information

Indicated for: Obsessive-compulsive disorder; treatment-resistant depression. TCA

Dosage & Administration

Typical dose range: 100–250 mg/day (divided)

Therapeutic level: Combined clomipramine + desmethylclomipramine 150–300 ng/mL.

Indications (label)

Obsessive-compulsive disorder; treatment-resistant depression.

View labelExact

Mechanism (brief)

Tricyclic antidepressant; potent serotonin reuptake inhibition with strong anticholinergic activity.

Metabolism & Half‑life

  • Metabolism: CYP2D6/CYP3A4 to desmethylclomipramine.
  • Half‑life: ~32–37 h.

Therapeutic Drug Monitoring (TDM)

Recommended: No

References