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Clomipramine

TCA • Brands: Anafranil

Last reviewed: 2025-09-27

General information

Indicated for: Obsessive-compulsive disorder; treatment-resistant depression.

Dosing & forms

  • Forms/strengths: —
  • Frequency: —
  • Food: —
  • Typical range: 100–250 mg/day (divided)

Mechanism (brief)

Tricyclic antidepressant; potent serotonin reuptake inhibition with strong anticholinergic activity.

Metabolism & Half‑life

  • Metabolism: CYP2D6/CYP3A4 to desmethylclomipramine.
  • Half‑life: ~32–37 h.

Therapeutic Drug Monitoring (TDM)

Recommended: Yes

Reference range: Combined clomipramine + desmethylclomipramine 150–300 ng/mL.

View labelExact

Monitoring highlights

  • ECG/QTc at baseline and dose escalations — Baseline and as indicated
  • TDM levels — After steady state and with dose changes

Sources