clomipramine
Adjunctive therapy • Brands: Anafranil
Last reviewed: 2025-10-05
General information
- Class: Adjunctive therapy
- Common US brands: Anafranil
- Therapeutic drug monitoring recommended; reference range 150–300 ng/mL.
- Last reviewed: 2025-10-05
Dosing & forms
- Forms/strengths: —
- Frequency: —
- Food: —
- Typical range: —
Mechanism (brief)
Tricyclic antidepressant; potent serotonin reuptake inhibition.
Metabolism & Half‑life
- Metabolism: CYP2D6, CYP3A4
- Half‑life: Single-dose mean 32 h; Steady-state mean 37 h
Therapeutic Drug Monitoring (TDM)
Recommended: Yes
Reference range: 150–300 ng/mL
Monitoring highlights
- —
Sources
- Anafranil (clomipramine) prescribing information — DailyMed (2024)
- APA Clinical Practice Guideline for the Treatment of Obsessive-Compulsive Disorder — American Psychiatric Association (2020)
- Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology: Update 2017 — Pharmacopsychiatry (2018)
- APA Clinical Practice Guideline for the Treatment of Depression — American Psychiatric Association (2023)