clonazepam
Adjunctive therapy • Brands: KLONOPIN
Last reviewed: 2025-12-29
General information
- Class: Adjunctive therapy
- Common US brands: KLONOPIN
- Therapeutic drug monitoring not routinely recommended.
- Last reviewed: 2025-12-29
Dosing & forms
- Forms/strengths: —
- Frequency: —
- Food: —
- Typical range: —
Mechanism (brief)
Benzodiazepine; enhances GABA‑A receptor activity.
Metabolism & Half‑life
- Metabolism: Hepatic
- Half‑life: Steady-state mean 35 h
Therapeutic Drug Monitoring (TDM)
Recommended: No
Monitoring highlights
- —
Sources
- Klonopin (clonazepam) prescribing information — DailyMed (2025)
- Evidence-based pharmacological treatment of anxiety disorders — Depression and Anxiety (2014)
- Benzodiazepines for catatonia: systematic review and meta-analysis — Schizophrenia Research (2018)
- ASAM guideline on benzodiazepines — Journal of Addiction Medicine (2020)
- Evidence-based consensus guidelines for the management of catatonia: recommendations from the British Association for Psychopharmacology — Journal of Psychopharmacology (2023)