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Desvenlafaxine

SNRI • Brands: Pristiq

Last reviewed: 2025-09-26

General information

Indicated for: Major depressive disorder.

Dosing & forms

  • Forms/strengths: —
  • Frequency: —
  • Food: —
  • Typical range: 50–100 mg once daily

Mechanism (brief)

Serotonin and norepinephrine reuptake inhibitor; active metabolite of venlafaxine.

Metabolism & Half‑life

  • Metabolism: Phase II (UGT) with minimal CYP2D6 involvement, minor CYP3A4.
  • Half‑life: ~11 h.

Therapeutic Drug Monitoring (TDM)

Recommended: No

View labelExact

Monitoring highlights

  • Blood pressure and pulse (dose-related increases) — Baseline and periodically
  • Renal function for dosing (reduce if CrCl <50 mL/min) — Baseline and periodically

Sources