disulfiram
Adjunctive therapy • Brands: Antabuse
Last reviewed: 2025-12-30
General information
- Class: Adjunctive therapy
- Common US brands: Antabuse
- Therapeutic drug monitoring not routinely recommended.
- Last reviewed: 2025-12-30
Dosing & forms
- Forms/strengths: —
- Frequency: —
- Food: —
- Typical range: —
Mechanism (brief)
Aldehyde dehydrogenase inhibitor used as aversive therapy for alcohol use disorder; can cause a severe and prolonged reaction if alcohol is consumed (label/guideline).
Metabolism & Half‑life
- Metabolism: Hepatic metabolism to diethyldithiocarbamate and other metabolites (label)
- Half‑life: —
Therapeutic Drug Monitoring (TDM)
Recommended: No
Monitoring highlights
- —
Sources
- Disulfiram tablets prescribing information — DailyMed (2025)
- Pharmacotherapy for adults with alcohol use disorders in outpatient settings: a systematic review and meta-analysis — JAMA (2014)
- The American Psychiatric Association Practice Guideline for the Pharmacological Treatment of Patients With Alcohol Use Disorder — American Journal of Psychiatry (2018)
- Anticraving therapy for alcohol use disorder: A clinical review — Neuropsychopharmacology Reports (2018)