Fluphenazine

General information

Indicated for: Schizophrenia; psychotic disorders (oral and depot).

Dosing & forms

• Forms/strengths: —
• Frequency: —
• Food: —
• Typical range: 5–20 mg/day (divided)

Mechanism (brief)

High-potency phenothiazine D2 antagonist.

Metabolism & Half‑life

• Metabolism: CYP2D6.
• Half‑life: ~15 h (oral); decanoate apparent half-life 7–10 days.

Therapeutic Drug Monitoring (TDM)

Recommended: No

Monitoring highlights

• EPS/AIMS exam — Each visit (AIMS q3-6 mo)
• Injection site (if depot) — Every visit

Sources

• Fluphenazine label — DailyMed (2025)