fluphenazine
Antipsychotic • Brands: Prolixin
Last reviewed: 2025-12-29
General information
- Class: Antipsychotic
- Common US brands: Prolixin
- Long-acting injectable formulation available.
- Therapeutic drug monitoring not routinely recommended.
- Last reviewed: 2025-12-29
Dosing & forms
- Forms/strengths: —
- Frequency: —
- Food: —
- Typical range: —
Mechanism (brief)
High-potency phenothiazine antipsychotic with strong dopamine D2 antagonism; long-acting decanoate available for depot dosing.
Metabolism & Half‑life
- Metabolism: CYP2D6
- Half‑life: Single-dose mean 15 h
Therapeutic Drug Monitoring (TDM)
Recommended: No
Long‑acting injectable (LAI)
Monitoring highlights
- —
Sources
- Fluphenazine decanoate prescribing information — DailyMed (2024)
- Triple advantages of injectable long acting second generation antipsychotics: relapse prevention, neuroprotection, and lower mortality — Schizophrenia Research (2018)
- The American Psychiatric Association Practice Guideline for the Treatment of Patients With Schizophrenia — American Psychiatric Association (2020)
- Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis — The Lancet (2013)
- CANMAT and ISBD Guidelines for the Management of Patients With Bipolar Disorder: 2021 Update — Bipolar Disorders (2021)