Iloperidone

General information

Indicated for: Schizophrenia in adults.

Dosing & forms

• Forms/strengths: —
• Frequency: —
• Food: —
• Typical range: 12–24 mg/day (divided)

Mechanism (brief)

D2/D3 and 5‑HT2A antagonism with high α1 affinity.

Metabolism & Half‑life

• Metabolism: CYP2D6 and CYP3A4.
• Half‑life: ~18 h (extensive metabolizers).

Therapeutic Drug Monitoring (TDM)

Recommended: No

Monitoring highlights

• Orthostatic blood pressure — Baseline and during titration
• ECG if risk factors (QT) — As clinically indicated
• Metabolic: weight, BMI, fasting lipids/glucose — Baseline, 3 mo, annually

Sources

• Iloperidone label — DailyMed (2025)