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Imipramine

TCA • Brands: Tofranil

Last reviewed: 2025-09-27

General information

Indicated for: Depression; childhood nocturnal enuresis.

Dosing & forms

  • Forms/strengths: —
  • Frequency: —
  • Food: —
  • Typical range: 100–200 mg/day (divided)

Mechanism (brief)

Tricyclic antidepressant; serotonin and norepinephrine reuptake inhibition with anticholinergic activity.

Metabolism & Half‑life

  • Metabolism: CYP2D6/CYP1A2 to desipramine.
  • Half‑life: ~19–24 h.

Therapeutic Drug Monitoring (TDM)

Recommended: Yes

Reference range: Combined imipramine + desipramine 150–300 ng/mL.

View labelExact

Monitoring highlights

  • ECG/QTc baseline and with dose escalations — Baseline and as indicated
  • Therapeutic drug monitoring — After steady state and with dose changes

Sources