Educational only — not medical advice.If you’re in crisis or thinking about suicide: call or text 988 (U.S.) or your local emergency number. Support resources.Under construction and review—see the updates log.
Typical dose range: Label trials initiated at 10 mg twice daily, with increases every 2–4 days as tolerated until effect, up to 80 mg/day in divided doses (label).
Therapeutic drug monitoring not routinely recommended.
Last reviewed: 2025-12-30
Dosing & forms
Forms/strengths: Oral tablets (label): 10 mg.
Frequency: Label trials initiated at 10 mg twice daily, with increases every 2–4 days as tolerated until effect, up to 80 mg/day in divided doses (label).
Typical range: Label trials initiated at 10 mg twice daily, with increases every 2–4 days as tolerated until effect, up to 80 mg/day in divided doses (label).
Mechanism (brief)
Irreversible, nonselective monoamine oxidase inhibitor (MAOI). Generally reserved for treatment-resistant depression because of dietary restrictions and high-risk drug interaction profile (label/clinical).
Before starting: review all prescription/OTC/supplement products and provide a written “do-not-combine” list; confirm understanding with teach-back (clinical).
Diet: counsel on tyramine restriction and continue dietary precautions for at least 14 days after discontinuation (label/clinical).
Vitals: monitor orthostatic blood pressure during titration and after dose changes; counsel on hydration and slow position changes (label/clinical).
Emergency symptoms (severe headache, chest pain, palpitations, stiff neck, fever, marked agitation/confusion) require urgent evaluation because they can signal hypertensive crisis or serotonin syndrome (label/clinical).
Mood: monitor for suicidality early in treatment and for mania/hypomania activation in patients with bipolar risk (class/clinical).