lorazepam
Adjunctive therapy • Brands: ATIVAN, LOREEV XR
Last reviewed: 2025-12-28
General information
- Class: Adjunctive therapy
- Common US brands: ATIVAN, LOREEV XR
- Therapeutic drug monitoring not routinely recommended.
- Last reviewed: 2025-12-28
Dosing & forms
- Forms/strengths: —
- Frequency: —
- Food: —
- Typical range: —
Mechanism (brief)
Benzodiazepine; positive allosteric modulator of GABA-A receptors.
Metabolism & Half‑life
- Metabolism: Glucuronidation
- Half‑life: Single-dose mean 12 h
Therapeutic Drug Monitoring (TDM)
Recommended: No
Monitoring highlights
- —
Sources
- Ativan (lorazepam) prescribing information — DailyMed (2025)
- ASAM guideline on benzodiazepines — Journal of Addiction Medicine (2020)
- Benzodiazepines for catatonia: systematic review and meta-analysis — Schizophrenia Research (2018)
- Evidence-based consensus guidelines for the management of catatonia: recommendations from the British Association for Psychopharmacology — Journal of Psychopharmacology (2023)
- Evidence-based pharmacological treatment of anxiety disorders — Depression and Anxiety (2014)