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Loxapine

FGA • Brands: Loxitane, Adasuve

Last reviewed: 2025-09-26

General information

Indicated for: Schizophrenia; acute agitation associated with schizophrenia or bipolar I (inhaled).

Dosing & forms

  • Forms/strengths: —
  • Frequency: —
  • Food: —
  • Typical range: 20–100 mg/day (divided)

Mechanism (brief)

Mid-potency D2 and 5‑HT2A antagonist with H1/M1 blockade.

Metabolism & Half‑life

  • Metabolism: CYP1A2, CYP3A4, CYP2D6 to active metabolites.
  • Half‑life: ~6–8 h (parent).

Therapeutic Drug Monitoring (TDM)

Recommended: No

View labelExact

Monitoring highlights

  • Metabolic: weight, BMI, fasting lipids/glucose — Baseline, annually
  • EPS monitoring — Each visit
  • Airway assessment if inhaled formulation — Prior to each dose

Sources