lurasidone

General information

• Class: Antipsychotic
• Common US brands: LATUDA
• Typical dose range: Adult schizophrenia: start 40 mg once daily with food; titrate in 40 mg increments to 40–160 mg/day based on response and tolerability.
• Therapeutic drug monitoring not routinely recommended.
• Last reviewed: 2026-02-12

Dosing & forms

• Forms/strengths: Oral tablets 20 mg, 40 mg, 60 mg, 80 mg, and 120 mg; each dose must be taken with ≥350 calories.
• Frequency: Adult schizophrenia: start 40 mg once daily with food; titrate in 40 mg increments to 40–160 mg/day based on response and tolerability.
• Food: Take with food.
• Typical range: Adult schizophrenia: start 40 mg once daily with food; titrate in 40 mg increments to 40–160 mg/day based on response and tolerability.

Mechanism (brief)

D2 and 5‑HT2A antagonism; 5‑HT7 antagonism; partial 5‑HT1A agonism.

Metabolism & Half‑life

• Metabolism: CYP3A4
• Half‑life: Steady-state mean 18 h

Therapeutic Drug Monitoring (TDM)

Recommended: No

Sources

• LATUDA (lurasidone) prescribing information — DailyMed (2026)
• The American Psychiatric Association Practice Guideline for the Treatment of Patients With Schizophrenia — American Psychiatric Association (2020)
• Effectiveness of lurasidone vs. quetiapine XR for relapse prevention in schizophrenia: a 12-month, double-blind, noninferiority study — Schizophrenia Research (2013)
• Lurasidone monotherapy in bipolar I depression: a randomized, double-blind, placebo-controlled study — American Journal of Psychiatry (2014)
• The CANMAT and ISBD Guidelines for the Management of Patients With Bipolar Disorder: 2021 Update — Bipolar Disorders (2021)
• Long-term safety and effectiveness of lurasidone in schizophrenia — Schizophrenia Research (2016)