Maprotiline

General information

Indicated for: Depressive disorders with neurovegetative features.

Dosing & forms

• Forms/strengths: —
• Frequency: —
• Food: —
• Typical range: 100–225 mg/day (divided or nightly)

Mechanism (brief)

Tetracyclic antidepressant; potent norepinephrine reuptake inhibition with antihistamine effects.

Metabolism & Half‑life

• Metabolism: CYP2D6 to active metabolites, elimination largely renal.
• Half‑life: ~51–52 h.

Therapeutic Drug Monitoring (TDM)

Recommended: Yes

Reference range: Target plasma 200–400 ng/mL (therapeutic drug monitoring).

Monitoring highlights

• ECG and seizure risk assessment (levels >600 ng/mL) — Baseline and with dose escalation
• TDM levels — After steady state and with clinical change

Sources

• Maprotiline label — DailyMed (2025)