PsychMed.orgMedication Reference Sheet

milsaperidone

Metabolism: CYP2D6, CYP3A4
Half‑life: Single-dose mean 26 h; Steady-state mean 33 h

Antipsychotic • Brands: Bysanti

Last reviewed: 2026-03-10

General information

Class: Antipsychotic
Common US brands: Bysanti
Typical dose range: Schizophrenia: titrate over 7 days from 1 mg BID to 6-12 mg BID (12-24 mg/day). Bipolar I mania: titrate over 5 days to 12 mg BID (24 mg/day).
Therapeutic drug monitoring not routinely recommended.
Last reviewed: 2026-03-10

Forms/strengths: Tablets: 1 mg, 2 mg, 4 mg, 6 mg, 8 mg, 10 mg, 12 mg.
Frequency: Schizophrenia: titrate over 7 days from 1 mg BID to 6-12 mg BID (12-24 mg/day). Bipolar I mania: titrate over 5 days to 12 mg BID (24 mg/day).
Food: With or without food.
Typical range: Schizophrenia: titrate over 7 days from 1 mg BID to 6-12 mg BID (12-24 mg/day). Bipolar I mania: titrate over 5 days to 12 mg BID (24 mg/day).

Dopamine D2 and serotonin 5-HT2A antagonist with adrenergic α1 blockade; active metabolite of iloperidone requiring structured titration.

Recommended: No

Label unavailableUnavailable