nefazodone
Adjunctive therapy • Brands: Serzone
Last reviewed: 2025-12-30
General information
- Class: Adjunctive therapy
- Common US brands: Serzone
- Therapeutic drug monitoring not routinely recommended.
- Last reviewed: 2025-12-30
Dosing & forms
- Forms/strengths: —
- Frequency: —
- Food: —
- Typical range: —
Mechanism (brief)
Serotonin antagonist and reuptake inhibitor (SARI-like): inhibits serotonin/norepinephrine uptake with 5-HT2 and α1 antagonism; notable for rare but life-threatening hepatic failure and strong CYP3A4 inhibition.
Metabolism & Half‑life
- Metabolism: CYP3A4
- Half‑life: Single-dose range 2–4 h
Therapeutic Drug Monitoring (TDM)
Recommended: No
Monitoring highlights
- —
Sources
- Nefazodone hydrochloride tablets prescribing information — DailyMed (2025)
- Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology: Update 2017 — Pharmacopsychiatry (2018)
- APA Clinical Practice Guideline for the Treatment of Depression — American Psychiatric Association (2023)
- CANMAT 2024 Clinical Guidelines for Major Depressive Disorder — Canadian Journal of Psychiatry (2024)