Perphenazine

General information

Indicated for: Schizophrenia; severe nausea and vomiting (short-term).

Dosing & forms

• Forms/strengths: —
• Frequency: —
• Food: —
• Typical range: 16–64 mg/day (divided)

Mechanism (brief)

Mid-potency phenothiazine D2 antagonist with moderate anticholinergic activity.

Metabolism & Half‑life

• Metabolism: CYP2D6, CYP1A2, CYP3A4.
• Half‑life: ~10 h.

Therapeutic Drug Monitoring (TDM)

Recommended: No

Monitoring highlights

• EPS/AIMS exam — Each visit
• Metabolic: weight, BMI, fasting lipids/glucose — Baseline, annually

Sources

• Perphenazine label — DailyMed (2025)