pimozide

General information

• Class: Antipsychotic
• Common US brands: Orap
• Therapeutic drug monitoring not routinely recommended.
• Last reviewed: 2025-12-30

Dosing & forms

• Forms/strengths: —
• Frequency: —
• Food: —
• Typical range: —

Mechanism (brief)

Dopamine receptor antagonist used primarily for Tourette’s disorder (tic suppression). Carries QT prolongation risk and has extensive contraindicated drug interactions (label).

Metabolism & Half‑life

• Metabolism: CYP2D6, CYP3A4
• Half‑life: —

Therapeutic Drug Monitoring (TDM)

Recommended: No

Monitoring highlights

• —

Sources

• Pimozide tablets prescribing information — DailyMed (2024)
• Practice guideline recommendations summary: Treatment of tics in people with Tourette syndrome and chronic tic disorders — Neurology (PMC) (2019)
• Torsade de Pointes (StatPearls) — StatPearls Publishing (NCBI Bookshelf) (2025)
• AGNP Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology — Pharmacopsychiatry (2018)