Quetiapine

Dosing & forms

• Forms/strengths: —
• Frequency: —
• Food: —
• Typical range: 300–800 mg/day

Mechanism (brief)

Antagonist at 5-HT2A and D2 (transient), strong H1 and alpha-1 activity.

Metabolism & Half‑life

• Metabolism: CYP3A4 primary.
• Half‑life: ~6 h (IR).

Therapeutic Drug Monitoring (TDM)

Recommended: No

Monitoring highlights

• Metabolic: weight, BMI, fasting lipids/glucose — Baseline, 3 mo, annually

In‑depth reading

• Pharmacological treatment for bipolar mania: network meta-analysis of RCTs. — Molecular Psychiatry (2022)
• Efficacy of Quetiapine in Bipolar Depression: Meta‑analysis — Meta‑analysis (2020)
• Quetiapine in schizophrenia and bipolar disorder: systematic review — Systematic review (2019)

Sources

• Quetiapine label — DailyMed (2025)