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Selegiline

MAOI • Brands: Eldepryl, Zelapar

Last reviewed: 2025-09-27

General information

Indicated for: Adjunctive treatment of major depressive disorder (with dietary precautions at higher doses).

Dosing & forms

  • Forms/strengths: —
  • Frequency: —
  • Food: —
  • Typical range: 5 mg twice daily (tablets) or 1.25–2.5 mg ODT once daily

Mechanism (brief)

Selective MAO-B inhibition at low doses; nonselective at ≥10 mg/day.

Metabolism & Half‑life

  • Metabolism: Hepatically via CYP2B6/CYP2C19/CYP3A4 to amphetamine-like metabolites.
  • Half‑life: ~10 h (pharmacodynamic effect longer).

Therapeutic Drug Monitoring (TDM)

Recommended: No

View labelExact

Monitoring highlights

  • Blood pressure and symptoms of hypertensive crisis — Baseline and periodically
  • Assess insomnia/agitation due to metabolites — Each visit

Sources