thioridazine
Antipsychotic • Brands: Mellaril
Last reviewed: 2025-12-30
General information
- Class: Antipsychotic
- Common US brands: Mellaril
- Therapeutic drug monitoring not routinely recommended.
- Last reviewed: 2025-12-30
Dosing & forms
- Forms/strengths: —
- Frequency: —
- Food: —
- Typical range: —
Mechanism (brief)
Low-potency phenothiazine first-generation antipsychotic (D2 antagonism) with prominent anticholinergic effects. Notable for dose-related QTc prolongation risk; labeling restricts use to schizophrenia after failure of other agents.
Metabolism & Half‑life
- Metabolism: CYP2D6
- Half‑life: —
Therapeutic Drug Monitoring (TDM)
Recommended: No
Monitoring highlights
- —
Sources
- Thioridazine hydrochloride tablets prescribing information — DailyMed (2025)
- Torsade de Pointes (StatPearls) — StatPearls Publishing (NCBI Bookshelf) (2025)
- The American Psychiatric Association Practice Guideline for the Treatment of Patients With Schizophrenia — American Psychiatric Association (2020)
- AGNP Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology — Pharmacopsychiatry (2018)